演讲嘉宾
演讲主题 PRESENTATION TOPIC
COVID-19 病原样抗原(PLA) 疫苗的免疫效力研究
Study on the efficacy of COVID-19 pathogen-like antigen (PLA) vaccine
侯百东
研究员
中国科学院生物物理研究所
Baidong Hou
Principle Investigator
Institute of Biophysics, CAS
中国科学院生物物理研究所(IBP)感染与免疫重点实验室。入选国家首批“青年千人计划”。1994-2001年间于北京协和医院从事危重病医学临床研究;2001-2011年间先后于美国范德堡大学和加州大学旧金山分校从事博士后研究;2011回国于IBP组建实验室。研究专注于抗体反应机理、B细胞免疫和新型疫苗设计。研究成果系统性揭示了B细胞抗原呈递功能在启动抗病毒免疫反应中的重要功能,对创新疫苗设计将产生深远影响。
Baidong Hou is currently a principle investigator in the key laboratory of infection and immunity at the Institute of Biophysics (IBP), Chinese Academy of Sciences. He studied medicine at Peking University and obtained his bachelor’s degree in 1994, and then practiced medicine at Peking Union Medical College (PUMC) Hospital. He completed his M.D. training in critical care medicine with Dr. Dechang Chen at PUMC at 2001. He shifted his interest to basic research and received his postdoctoral training first in Dr. Douglas Vaughan’s lab at Vanderbilt University and then in Dr. Anthony DeFranco’s lab at University of California, San Francisco (UCSF). In 2011, he was recruited by IBP and moved back to China to establish his own lab. His research interest is to understanding the mechanism by which the adaptive immunity, especially B cell antibody response is regulated by innate immune signals in complex conditions such as viral infection and autoimmunity. His lab developed a serial of new tools and methods that allow them to examine antigen-specific B cell responses to a novel virus-like particle antigen that can closely mimics the properties of some viruses. These new tools are helping them to undercover some previously unappreciated functions of B cells that could have profound impact on vaccine design and therapy for autoimmunity.